![]() We determined the crystal structures of the protruding domain of the GI.9 capsid protein in the presence or absence of Lewis antigens. In this study, we demonstrate that the GI.9 norovirus preferentially binds Lewis antigens over blood group A, B, and H antigens, as revealed by an HBGA binding assay using virus-like particles. However, the molecular interactions between host antigens and the GI.9 capsid protein have not been investigated in detail. Genogroup I, genotype 9 (GI.9) is the most recently identified genotype within genogroup I, whose representative strain is the Vancouver 730 norovirus. Histo-blood group antigens (HBGAs) are thought to play a major role among the host cellular factors influencing norovirus infection. Noroviruses have been identified as major causative agents of acute nonbacterial gastroenteritis in humans. ![]()
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